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KMID : 0608520100160020167
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Korean Journal of Oriental Medicine
2010 Volume.16 No. 2 p.167 ~ p.179
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Preventive Effects of Daekumeumja on Fatty Degeneration of Liver and Immunosuppression Induced by Alcohol
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Kim Jeong-Ja
Seo Bu-Il
Park Gyu-Ryeol
Choi Hong Sik
Kim Seong-Mo
Woo Chang-Hoon
Koo Jin-Suk
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Abstract
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Objective : The present study has been undertaken to investigate the preventive effects of Daekumeumja on fatty degeneration of liver and immunosuppression induced by alcohol in rats.
Method : Except for the normal group, we fed rat on 25% alcohol for 55 days. And Daekumeumja(DK) extract was administrated for the same period. We measured the serum component in rat"s blood, weight of internal organs, liver triglyceride contents, histomorphometry and histopathological observation of internal organs.
Results :1. In the change measurement of serum components, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant decrease of AST, ALT, albumin, ALP and triglyceride in comparison with those of the alcohol control group.
2. In the change measurement of internal organ"s weight, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant increase of relative body weights of liver, thymus and spleen in comparison with those of the alcohol control group.
3. DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant decrease of hepatic triglyceride contents in comparison with those of the alcohol control group.
4. In histomorphometrical changes of liver, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant decrease of numbers of hepatocytes occupied by over 10 % lipid droplets, percentages of regions occupied by lipid droplets and mean diameters of hepatocytes in comparison with those of the alcohol control group. In histomorphometrical changes of thymus, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant increase of lobular thickness and cortex thickness in comparison with those of the alcohol control group. In histomorphometrical changes of spleen, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed significant increase of splenic thicknesses, numbers of white pulps and mean diameters of white pulps in comparison with those of the alcohol control group.
5. In histopathological changes of liver, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed effective inhibition of severe fatty changes in comparison with those of the alcohol control group. In histopathological changes of thymus and spleen, DK group(50 ㎎/㎏, 200 ㎎/㎏) showed effective inhibition of atrophic changes in comparison with those of the alcohol control group.
Conclusions : Reviewing these experimental results, it appears that Daekumeumja have pharmaceutical preventive efficacy on fatty degeneration of liver and immunosuppression induced by alcohol in rats.
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KEYWORD
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Daekumeumja, alcohol, fatty degeneration, liver, immunosuppression, thymus, spleen
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